Positive Feedback between MAP Kinase and Mos duringXenopusOocyte Maturation
نویسندگان
چکیده
منابع مشابه
Inhibition of mos-induced Oocyte Maturation by Protein Kinase A
The relationship between the mos protooncogene protein and cAMP-dependent protein kinase (PKA) during the maturation of Xenopus oocytes was investigated. Microinjection of the PKA catalytic subunit (PKA0 into Xenopus oocytes inhibited oocyte maturation induced by the mos product but did not markedly affect the autophosphorylation activity of injected mos protein. By contrast, PKA~ did not inhib...
متن کاملInhibition of mos-induced oocyte maturation by protein kinase A
The relationship between the mos protooncogene protein and cAMP-dependent protein kinase (PKA) during the maturation of Xenopus oocytes was investigated. Microinjection of the PKA catalytic subunit (PKAc) into Xenopus oocytes inhibited oocyte maturation induced by the mos product but did not markedly affect the autophosphorylation activity of injected mos protein. By contrast, PKAc did not inhi...
متن کاملThe interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Throughout oocyte maturation, and subsequently during the first mitotic cell cycle, the MAP kinase cascade and cyclin-B-Cdc2 kinase are associated with the control of cell cycle progression. Many roles have been directly or indirectly attributed to MAP kinase and its influence on cyclin-B-Cdc2 kinase in different model systems; yet a principle theme does not emerge from the published literature...
متن کاملMos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse.
Mos is normally expressed during oocyte meiotic maturation in vertebrates. However, apart from its cytostatic factor (CSF) activity, its precise role during mouse meiosis is still unknown. First, we analyzed its role as a MAP kinase kinase kinase. Mos is synthesized concomitantly with the activation of MAP kinase in mouse oocytes. Moreover, MAP kinase is not activated during meiosis in oocytes ...
متن کاملmolecular basis of meiotic maturation and apoptosis of oocytes, sperm-oocyte interactions and early cleavage of embryos in mice, role of phosphatidylinositol 3-kinase, mos, fas-fas ligand, integrinα6 and map kinase
the interaction between molecular biology and embryology made an extensive progress in the research on gametogenesis, fertilization and early embryogenesis in mice. in this article, molecules involving in meiotic maturation and apoptosis of oocytes, sperm-oocyte interactions and early cleavage of fertilized embryos in mice are described including our recent following experiments. 1) phosphatidy...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1996
ISSN: 0012-1606
DOI: 10.1006/dbio.1996.0277